Co-directed by Drs. Khushboo Verma and Satwant Kumar, advancing Alzheimer's disease and related dementias through biomarkers, brain-systems research, and real-world care pathways.
We treat rigor as a form of compassion: clear endpoints, transparent methods, and results you can cite.
New preprint (under review; not clinical guidance)
A methods-focused preprint on enrichment, estimand mismatch, and selection–inference reuse (“double dipping”).
Co-directors and partners in life and in science, translating dementia research into better care across biomarkers, clinically grounded AI, and real-world care pathways.
Multimodal biomarkers — PET, MRI, and psychometrics for rigorous phenotyping
Clinically grounded AI — building tools that respect evidence, bias, and workflow
Implementation science — turning results into scalable care pathways
Quick start
Core Pillars
Three tightly linked programs organize our work—moving us toward a world without dementia, from multimodal biomarkers to implementation in real-world care.
Integrated Biomarkers
Longitudinal, multimodal modeling of secondary datasets (e.g., OASIS-3) integrating amyloid PET, structural MRI, and psychometrics to quantify continuous dementia severity and trajectories across distributed cortical and subcortical systems.
Care Pathways
Closed-loop Express Dementia Care (EDCC) pathway focused on workflow design, caregiver navigation, and system-level measurement of access and readiness for disease-modifying therapies in rural East Texas.
Systems & AI
Combining primate systems neuroscience with clinically grounded AI, spanning lesion–symptom mapping, physician-scored benchmarks (ExpertMedQA), and BooksMed decision support.
Methods & modalities
A systems neuroscience foundation with translational methods that scale to real datasets and real clinics—because better measurement is a path to better care.
PET and neuropsychological phenotyping with transparent evaluation metrics and clinically interpretable endpoints.
Multicenter stroke lesion segmentation supporting voxel-based lesion–symptom mapping and scalable imaging workflows.
Trajectory and severity modeling designed to surface assumptions, uncertainty, and sensitivity to cohort definitions.
Physician-scored benchmarks (ExpertMedQA) and state-of-the-art performance validation for expert-level clinical queries.
Express Dementia Care (EDCC) workflows, readiness measurement, and equity-focused operational evaluation.
Mechanistic grounding from causal and computational systems neuroscience to inform translational hypotheses and model design.
Collaboration
Our north star is a world without dementia. We work like an academic lab: clear endpoints, explicit assumptions, and outputs that stand up to review.
01
Define the clinical context, primary endpoint, and success criteria. We align hypotheses with measurement constraints and realistic effect sizes.
02
Agree on data access, IRB/DUA requirements, and a reproducible analysis plan. We prioritize transparent evaluation and sensitivity analyses.
03
Produce figures, methods text, and artifacts that support abstracts and manuscripts—plus code and documentation when release is feasible.
Featured Work
Selected projects spanning biomarker science, health disparities, and systems neuroscience—built for measurable impact.
Physician-scored benchmark across seven countries evaluating expert neurology scenarios and what it takes for clinical AI to be trusted in practice.
OASIS-3 secondary data analysis integrating amyloid PET and neuropsychological testing to model continuous dementia severity and cognitive decline—supporting more precise phenotyping and earlier detection.
Open-source, multicenter-validated stroke lesion segmentation (Diagnostics 2022) enabling scalable, reproducible voxel-based lesion–symptom mapping analyses.
Closed-loop EDCC pathway for rapid triage, caregiver navigation, and measurement of readiness and equity for disease-modifying therapies in rural East Texas—designed to extend evidence-based care beyond major centers.
YouTube
Recent public education videos on dementia care, caregiver support, and communication strategies.
2/20/2026
Are memory supplements really effective or just marketing? In this video, Dr. Khushboo Verma, a behavioral neurologist, breaks down the CLEAR Framework, a si…
2/5/2026
Does anesthesia cause dementia—or is something else going on? If your older loved one seems more confused after surgery, families deserve clear answers. In t…
1/30/2026
If your loved one with dementia suddenly “walks away,” you are not alone, and you are not failing. Dementia wandering can happen quickly, and it’s often driv…
